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Further studies and reviews have highlighted the significance of anabolic steroids for potentially aiding in repairing of damaged skeletal muscles following an injury. However, very little research has yet been published on the effects and potential mechanisms involved in enhancing skeletal muscle adaptations following high-intensity exercise and resistance training. This study investigated the effects of testosterone and its metabolites on the mechanical properties and muscle protein breakdown. In four separate experiments, young male untrained men were randomly assigned, in a double-blind fashion, to an injection of testosterone or a placebo (0.9% v/v) and exercised 3 times per week for a period of 2 to 4 wk followed by another experiment. The mechanical properties of the elbow flexors, forearm extensors, shoulder extensors, knee extensors, and back extensors were determined as well as the mRNA and protein content of key signal transducer proteins of the skeletal muscle myosin heavy chain and myosin heavy chain component. The data revealed that both testosterone and its metabolites (metandronic luteinizing hormone and corticotropin-releasing hormone, respectively), did induce a slight attenuation in the forces of the elbow flexors and forearm extenors relative to placebo or the equivalent dose of placebo. Although the mean force on the forearm extenors, shoulder extensors, knee extensors and back extensors was significantly greater as the dose of testosterone was increased to 0.9% v/v, these values were not affected by its metabolite. There was an increased mechanical adaptation of the elbow flexors (p less than 0.05) that was not altered by either testosterone or its metabolite. In contrast to the effects on the mechanical properties and myosin heavy chain and myosin heavy chain component, there was little to no effect (p less than 0.05) on muscle protein breakdown. These results indicate that the use of testosterone and its metabolite can augment bone and muscle tissue responses to exercise and resistance training for improving the mechanical properties of the elbow flexors, forearm extension, knee flexors, back extensors, and back extensors, respectively. The use of testosterone is safe and has the potential to enhance muscle adaptations with the sole consequence being to mitigate muscle tissue damage during high-intensity exercise and resistance training. Related Article:
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